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Elevated Pulse Pressure in Anesthetized Subjects Before Cardiopulmonary Bypass Is Associated Strongly With Postoperative Acute Kidney Injury Stage.

Identifieur interne : 000504 ( Main/Exploration ); précédent : 000503; suivant : 000505

Elevated Pulse Pressure in Anesthetized Subjects Before Cardiopulmonary Bypass Is Associated Strongly With Postoperative Acute Kidney Injury Stage.

Auteurs : Ludmil Mitrev [États-Unis] ; Kelly G. Speich [États-Unis] ; Spencer Ng [États-Unis] ; Albina Shapiro [États-Unis] ; Talia Ben-Jacob [États-Unis] ; Majid Khan [États-Unis] ; Vineeth Nagubandi [États-Unis] ; John Gaughan [États-Unis]

Source :

RBID : pubmed:30713052

Descripteurs français

English descriptors

Abstract

OBJECTIVE

To investigate whether pulse pressure (PP) in anesthetized patients undergoing cardiac surgery before and after cardiopulmonary bypass (CPB) is associated with higher postoperative acute kidney injury (AKI) stage.

DESIGN

Retrospective cohort of 597 patients undergoing cardiac surgery.

SETTING

Single academic health care center.

PARTICIPANTS

Adult patients undergoing cardiac surgery requiring CPB (coronary artery bypass grafting, valve, aortic, or combined surgery).

INTERVENTIONS

Pulse pressure was assessed during 3 time periods: pre- and post-CPB, and in the first postoperative hour in the intensive care unit. Pulse pressure, patient characteristics, and intraoperative variables were evaluated using univariable generalized estimating equation analysis for a relationship with AKI stage. Significant risk factors from the univariable analysis then were evaluated in a multivariable generalized estimating equation analysis. Acute kidney injury stage was defined using the Acute Kidney Injury Network criteria.

PRIMARY OUTCOME

Stage of postoperative AKI.

MEASUREMENTS AND MAIN RESULTS

Intraoperative prebypass PP was associated independently and significantly with postoperative AKI stage (odds ratio 1.0107; 95% Confidence Interval, 1.0046-1.0168; p = 0.0005). For every 1-mmHg increase in PP, the odds of a higher AKI stage increased 1.07%. The 2 other periods were not found to be significant predictors of AKI stage.

CONCLUSION

During general anesthesia prior to initiation of CPB, elevated PP is significantly predictive of postoperative AKI stage. This finding merits further research.


DOI: 10.1053/j.jvca.2019.01.019
PubMed: 30713052


Affiliations:


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Le document en format XML

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<front>
<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVE</b>
</p>
<p>To investigate whether pulse pressure (PP) in anesthetized patients undergoing cardiac surgery before and after cardiopulmonary bypass (CPB) is associated with higher postoperative acute kidney injury (AKI) stage.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>DESIGN</b>
</p>
<p>Retrospective cohort of 597 patients undergoing cardiac surgery.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>SETTING</b>
</p>
<p>Single academic health care center.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>PARTICIPANTS</b>
</p>
<p>Adult patients undergoing cardiac surgery requiring CPB (coronary artery bypass grafting, valve, aortic, or combined surgery).</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>INTERVENTIONS</b>
</p>
<p>Pulse pressure was assessed during 3 time periods: pre- and post-CPB, and in the first postoperative hour in the intensive care unit. Pulse pressure, patient characteristics, and intraoperative variables were evaluated using univariable generalized estimating equation analysis for a relationship with AKI stage. Significant risk factors from the univariable analysis then were evaluated in a multivariable generalized estimating equation analysis. Acute kidney injury stage was defined using the Acute Kidney Injury Network criteria.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>PRIMARY OUTCOME</b>
</p>
<p>Stage of postoperative AKI.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>MEASUREMENTS AND MAIN RESULTS</b>
</p>
<p>Intraoperative prebypass PP was associated independently and significantly with postoperative AKI stage (odds ratio 1.0107; 95% Confidence Interval, 1.0046-1.0168; p = 0.0005). For every 1-mmHg increase in PP, the odds of a higher AKI stage increased 1.07%. The 2 other periods were not found to be significant predictors of AKI stage.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>During general anesthesia prior to initiation of CPB, elevated PP is significantly predictive of postoperative AKI stage. This finding merits further research.</p>
</div>
</front>
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<Year>2020</Year>
<Month>03</Month>
<Day>09</Day>
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<Issue>6</Issue>
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<Title>Journal of cardiothoracic and vascular anesthesia</Title>
<ISOAbbreviation>J Cardiothorac Vasc Anesth</ISOAbbreviation>
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<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate whether pulse pressure (PP) in anesthetized patients undergoing cardiac surgery before and after cardiopulmonary bypass (CPB) is associated with higher postoperative acute kidney injury (AKI) stage.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Retrospective cohort of 597 patients undergoing cardiac surgery.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">Single academic health care center.</AbstractText>
<AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">Adult patients undergoing cardiac surgery requiring CPB (coronary artery bypass grafting, valve, aortic, or combined surgery).</AbstractText>
<AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">Pulse pressure was assessed during 3 time periods: pre- and post-CPB, and in the first postoperative hour in the intensive care unit. Pulse pressure, patient characteristics, and intraoperative variables were evaluated using univariable generalized estimating equation analysis for a relationship with AKI stage. Significant risk factors from the univariable analysis then were evaluated in a multivariable generalized estimating equation analysis. Acute kidney injury stage was defined using the Acute Kidney Injury Network criteria.</AbstractText>
<AbstractText Label="PRIMARY OUTCOME" NlmCategory="METHODS">Stage of postoperative AKI.</AbstractText>
<AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">Intraoperative prebypass PP was associated independently and significantly with postoperative AKI stage (odds ratio 1.0107; 95% Confidence Interval, 1.0046-1.0168; p = 0.0005). For every 1-mmHg increase in PP, the odds of a higher AKI stage increased 1.07%. The 2 other periods were not found to be significant predictors of AKI stage.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">During general anesthesia prior to initiation of CPB, elevated PP is significantly predictive of postoperative AKI stage. This finding merits further research.</AbstractText>
<CopyrightInformation>Copyright © 2019 Elsevier Inc. All rights reserved.</CopyrightInformation>
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<ForeName>Majid</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Department of Nephrology, Cooper University Hospital, Camden, NJ; Hypertension Nephrology Associates, Willow Grove, PA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Nagubandi</LastName>
<ForeName>Vineeth</ForeName>
<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Department of Anesthesiology, Division of Cardiothoracic Anesthesiology, Cooper University Hospital, Camden, NJ.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Gaughan</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo>
<Affiliation>Biostatistics, Cooper University Healthcare, Camden, NJ.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
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<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2019</Year>
<Month>01</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>United States</Country>
<MedlineTA>J Cardiothorac Vasc Anesth</MedlineTA>
<NlmUniqueID>9110208</NlmUniqueID>
<ISSNLinking>1053-0770</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList>
<CommentsCorrections RefType="CommentIn">
<RefSource>J Cardiothorac Vasc Anesth. 2019 Jun;33(6):1627-1628</RefSource>
<PMID Version="1">30928283</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D058186" MajorTopicYN="N">Acute Kidney Injury</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading>
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<MeshHeading>
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<MeshHeading>
<DescriptorName UI="D000768" MajorTopicYN="N">Anesthesia, General</DescriptorName>
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<DescriptorName UI="D002315" MajorTopicYN="N">Cardiopulmonary Bypass</DescriptorName>
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<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<DescriptorName UI="D009017" MajorTopicYN="N">Morbidity</DescriptorName>
<QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
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<MeshHeading>
<DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D057234" MajorTopicYN="N">Preoperative Period</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
<QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">acute kidney injury</Keyword>
<Keyword MajorTopicYN="N">cardiac surgery</Keyword>
<Keyword MajorTopicYN="N">cardiopulmonary bypass</Keyword>
<Keyword MajorTopicYN="N">pulse pressure</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2018</Year>
<Month>07</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2019</Year>
<Month>2</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2020</Year>
<Month>3</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2019</Year>
<Month>2</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">30713052</ArticleId>
<ArticleId IdType="pii">S1053-0770(19)30019-9</ArticleId>
<ArticleId IdType="doi">10.1053/j.jvca.2019.01.019</ArticleId>
</ArticleIdList>
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</pubmed>
<affiliations>
<list>
<country>
<li>États-Unis</li>
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<region>
<li>New Jersey</li>
<li>Pennsylvanie</li>
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<country name="États-Unis">
<region name="New Jersey">
<name sortKey="Mitrev, Ludmil" sort="Mitrev, Ludmil" uniqKey="Mitrev L" first="Ludmil" last="Mitrev">Ludmil Mitrev</name>
</region>
<name sortKey="Ben Jacob, Talia" sort="Ben Jacob, Talia" uniqKey="Ben Jacob T" first="Talia" last="Ben-Jacob">Talia Ben-Jacob</name>
<name sortKey="Gaughan, John" sort="Gaughan, John" uniqKey="Gaughan J" first="John" last="Gaughan">John Gaughan</name>
<name sortKey="Khan, Majid" sort="Khan, Majid" uniqKey="Khan M" first="Majid" last="Khan">Majid Khan</name>
<name sortKey="Nagubandi, Vineeth" sort="Nagubandi, Vineeth" uniqKey="Nagubandi V" first="Vineeth" last="Nagubandi">Vineeth Nagubandi</name>
<name sortKey="Ng, Spencer" sort="Ng, Spencer" uniqKey="Ng S" first="Spencer" last="Ng">Spencer Ng</name>
<name sortKey="Shapiro, Albina" sort="Shapiro, Albina" uniqKey="Shapiro A" first="Albina" last="Shapiro">Albina Shapiro</name>
<name sortKey="Speich, Kelly G" sort="Speich, Kelly G" uniqKey="Speich K" first="Kelly G" last="Speich">Kelly G. Speich</name>
</country>
</tree>
</affiliations>
</record>

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